Journal
FUTURE LIPIDOLOGY
Volume 2, Issue 2, Pages 229-237Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17460875.2.2.229
Keywords
1-acylglycerol-3phosphate acyltransferase; desnutrin/adipose triglyceride lipase; diacylglycerol acyltransferase; glycerol-3phosphate acyltransferase; hormone-sensitive lipase; lipolysis; phosphatidic acid phosphatase; triacylglycerol
Categories
Funding
- NIDDK NIH HHS [R01 DK093928, R01 DK075682-03, R01 DK075682, T32 DK061918] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK061918, R01DK075682, R01DK093928] Funding Source: NIH RePORTER
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Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.
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