Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 18, Issue 2, Pages 216-223Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.01.009
Keywords
RNA localisation; local translation; neurons; nervous system; synaptic plasticity
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The localisation of specific RNAs is a widely employed mechanism to generate asymmetry in various biological systems, e.g. during embryonic development and cellular differentiation. Here, we highlight the importance of RNA localisation in mature neurons. Specific examples of mRNAs localised in neurons are those encoding Arc, beta-actin, CaMKII alpha and MAP2. Moreover, non-coding RNAs, such as BC1/BC200 and microRNAs (miRNAs), which play important roles in the translational regulation of localised mRNAs, receive increasing attention. The process of RNA localisation, including RNP biogenesis, transport, anchoring and translational control, and the importance of RNA localisation for the function of the nervous system are discussed. (C) 2007 Elsevier Ltd. All rights reserved.
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