Journal
CANCER LETTERS
Volume 264, Issue 1, Pages 93-100Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.01.022
Keywords
Styela clava tunic; chondroitin sulfate; iNOS; VCAM-1; NF-kappa B; akt
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Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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