Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 10, Issue 2, Pages 169-175Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2007.03.014
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Funding
- NIGMS NIH HHS [R01 GM068720, R01 GM068720-03, GM068720] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068720] Funding Source: NIH RePORTER
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Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.
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