Journal
TRENDS IN IMMUNOLOGY
Volume 28, Issue 4, Pages 150-153Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.02.001
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The gastrointestinal immune system consists of immune cells in organized gut-associated lymphoreticular tissues (GALT) and diffuse lamina propria, which give rise to mucosal secretory IgA antibody responses. A recent study showed that the retinoic acid produced by GALT dendritic cells (DCs) imprints B cells for gut homing. Surprisingly, GALT DCs, together with interleukin-5 (IL-5) and IL-6, also provided a milieu for both B cell switching to IgA and IgA synthesis.
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