Journal
NANOMEDICINE
Volume 2, Issue 2, Pages 153-167Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17435889.2.2.153
Keywords
atherosclerosis; cancer; data mining; fluorescence imaging; high-throughput screening; iron oxide; magnetic nanoparticle; magnetic resonance imaging; molecular imaging; peptide targeting; phage display
Funding
- NCI NIH HHS [U54-CA119349, U54-CA126515] Funding Source: Medline
- NHLBI NIH HHS [UO1-HL080731] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U54CA119349, U54CA126515] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL080731] Funding Source: NIH RePORTER
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Magnetic nanoparticles and their magnetofluorescent analogues have become important tools for in vivo imaging using magnetic resonance imaging and fluorescent optical methods. A number of monodisperse magnetic nanoparticle preparations have been developed over the last decade for angiogenesis imaging, cancer staging, tracking of immune cells (monocyte/macrophage, T cells) and for molecular and cellular targeting. Phage display and data mining have enabled the procurement of novel tissue- or receptor-specific peptides, while high-throughput screening of diversity-oriented synthesis libraries has identified small molecules that permit or prevent uptake by specific cell types. Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.
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