Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 17, Issue 2, Pages 88-93Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2007.02.001
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM064475] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM64475, R01 GM064475] Funding Source: Medline
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The packaging of the eukaryotic genome into chromatin severely restricts the access of the transcriptional machinery to the DNA. Recent studies reveal that histories are removed and replaced to enable or restrict, respectively, access of the transcription machinery to regulate transcription. Chromatin disassembly at promoters enables transcriptional activation, whereas promoter chromatin reassembly represses transcription. Histone loss also occurs within transcription units to enable passage of the RNA polymerase, but in this case the histories are rapidly replaced, sometimes by 'variant' histories with specific properties that might serve as a memory of transcriptional competence. Furthermore, the ultimate goal of some epigenetic modifications might well turn out to be the regulation of histone occupancy on the DNA.
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