Journal
CANCER JOURNAL
Volume 18, Issue 1, Pages 89-99Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PPO.0b013e318244d8ae
Keywords
Drug delivery; convection-based delivery; nanocarriers; gene therapy; brain cancer stem cells
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Funding
- National Institutes of Health [CA149128]
- NATIONAL CANCER INSTITUTE [R01CA149128] Funding Source: NIH RePORTER
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Brain tumors-particularly glioblastoma multiforme-pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insufficient with nearly universal recurrence. A major reason for this failure is the difficulty of delivering therapeutic agents to the brain: better delivery approaches are needed to improve treatment. In this article, we summarize recent progress in drug delivery to the brain, with an emphasis on convection-enhanced delivery of nanocarriers. We examine the potential of new delivery methods to permit novel drug- and gene-based therapies that target brain cancer stem cells and discuss the use of nanomaterials for imaging of tumors and drug delivery.
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