Journal
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Volume 24, Issue 3, Pages 179-188Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010601166421
Keywords
blood platelet; bone marrow; human cytomegalovirus; idiopathic thrombocytopenic purpura
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This project explores the specificity of myeloid human cytomegalovirus (HCMV) infection in pathogenesis of idiopathic thrombocytopenic purpura (ITP). Eighty-one subjects with ITP were observed. HCMV early antigen and related myeloid cells in bone marrow, and platelet, HCMV IgM, and IgG in blood were tested. The results presented potent evidence that myeloid HCMV infection is a specific factor in children's ITP: patients of ITP with myeloid HCMV infection had a tendency for exacerbation, refractoriness, and chronic advance. However, HCMV did not affect the quantity of megakaryocyte, which showed the complicated relationships between HCMV and ITP.
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