Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 128, Issue 1, Pages 92-105Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.11.016
Keywords
inflammaging; inflammation and anti-inflammation; human studies; aging and longevity; systems biology
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A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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