Journal
CANCER INVESTIGATION
Volume 32, Issue 8, Pages 423-429Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2014.933237
Keywords
Brain Tumors; Cancer Biomarkers; Circulating Biomarkers; Proteins; Glioma
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Funding
- Robert H. Gross Memorial Fund
- Retired Professional Fire Fighters Cancer Fund, Inc. (RPFFCF)
- Sidney Kimmel Comprehensive Cancer Center core grant [P30CA006973]
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Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.
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