Journal
CANCER INVESTIGATION
Volume 32, Issue 6, Pages 226-235Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2014.905587
Keywords
Chemotherapy; Gliobastoma multiforme; Melissa officinali essential oil; Citral
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Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Instituto Nacional para Pesquisa Translacional em Saude e Ambiente na Regiao Amazonica/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/MCT, Brazil (INCT-INPeTAm/CNPq/MCT)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and caspase-3 activation. Antioxidant prevented citral-induced death, indicating its dependence on the production of reactive oxygen species. Citral downmodulated the activity and inhibited the expression of multidrug resistance associated protein 1 (MRP1). These results show that EO, through its major component, citral, may be of potential interest for the treatment of GBM.
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