Journal
CANCER INVESTIGATION
Volume 32, Issue 8, Pages 394-401Publisher
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2014.922569
Keywords
miRNA; NSCLC; Early detection; Prognosis
Categories
Funding
- Natural Science Foundation of Zhejiang [Y2110960]
- Science and Technology Bureau of Zhoushan [2011C12039, 2012C13023, 10137]
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Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e andmiR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.
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