Journal
CANCER INVESTIGATION
Volume 31, Issue 7, Pages 461-471Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2013.820318
Keywords
Pancreatic cancer; Prognostic studies; Invasion and metastasis
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Funding
- Indian Council of Medical Research (ICMR), New Delhi
- Council of Scientific and Industrial Research (CSIR), New Delhi
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In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor tissues examined. Staining intensity of cathepsin L was significantly higher in the tumor stroma compared to tumor epithelium while MMP-2 staining showed no such difference. Both proteases showed correlation with some of the clinicopathological parameters but only cathepsin L expression in tumor epithelium predicted a poor prognosis for the disease.
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