Journal
CANCER INVESTIGATION
Volume 31, Issue 5, Pages 336-345Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2013.793699
Keywords
CTLA-4; Single nucleotide polymorphisms; Melanoma; CTLA-4 blockade; Overall survival
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Funding
- Ricerca Sanitaria Regione Liguria, Italy [Dgr 563/2009]
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CTLA-4 blockade with monoclonal antibodies can lead to cancer regression in patients with metastatic melanoma (MM). CTLA-4 gene polymorphisms may influence the response to anti-CTLA-4 antibodies although few data are available regarding this issue. We analyzed six CTLA-4 single nucleotide polymorphisms (-1661A>G,-1577G>A, -658C>T, -319C> T, +49A>G, and CT60G>A) in 14 Italian MM patients and 45 healthy subjects. We found a significant association between the -1577G/A and CT60G/A genotypes and improved overall survival (Pc < 0.006, Bonferroni corrected), further confirmed by the diplotype analysis (-1577&CT60 GG-AA diplotype, p < 0.001). A positive trend toward an association between these genotypes and response to therapy was also observed.
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