Journal
CANCER INVESTIGATION
Volume 30, Issue 3, Pages 231-235Publisher
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2012.656862
Keywords
Angiogenesis; Cancer biomarkers; Non-small cell lung cancer; Clinical trials; VEGF
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Funding
- Breathe California
- Colombo Trust (HW)
- NIH [1 R01 HL074267-01]
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We retrospectively analyzed hematologic parameters in 22 patients with advanced, nonsquamous, NSCLC undergoing VEGF inhibition on a phase II clinical trial of bevacizumab, carboplatin, and gemcitabine. We also examined TTP in relation to hemoglobin changes. Median hemoglobin increased significantly from a 12.9 g/dL pretreatment to 13.8 g/dL (p = .01) after the second cycle of maintenance bevacizumab until the first off cycle measurement. There was no difference in TTP in patients who achieved a rise in hemoglobin compared with patients who did not (median 238 days vs. 268 days, p = .38.) Maintenance bevacizumab is associated with increased hemoglobin in advanced, nonsquamous, NSCLC patients.
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