Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 22, Issue 6, Pages 685-695Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360601164903
Keywords
propofol; monophenol; diphenol; antioxidant activity; dimeric form; radical scavenging
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In this study, di(2,6-dimethylphenol) (Di-DMP), di(2,6-diisopropylphenol) (Di-DIP, dipropofol) and di( 2,6-di-t-butylphenol) (Di-DTP) were synthesized by the reaction of monomeric phenol derivatives with catalytic CuCl( OH). TMEDA and Na2S2O4. Their antioxidant capacity and radical scavenging activity were examined using different in vitro methodologies such as 1,1-diphenyl- 2-picryl-hydrazyl (DPPH center dot) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline6- sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity by ferric thiocyanate, total reducing power by potassium ferricyanide reduction method, superoxide anion radical scavenging, hydrogen peroxide scavenging and ferrous ions chelating activities.
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