Journal
CANCER INVESTIGATION
Volume 30, Issue 5, Pages 343-363Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2012.664670
Keywords
Neuroblastoma; Mouse model; MYCN; Microenvironment
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Funding
- National Institutes of Health, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
- Children's Cancer Foundation
- National Cancer Institute, National Institutes of Health [N01-CO-12400]
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Using two MYCN transgenic mouse strains, we established 10 transplantable neuroblastoma cell lines via serial orthotopic passage in the adrenal gland. Tissue arrays demonstrate that by histochemistry, vascularity, immunohistochemical staining for neuroblastoma markers, catecholamine analysis, and concurrent cDNA microarray analysis, there is a close correspondence between the transplantable lines and the spontaneous tumors. Several genes closely associated with the pathobiology and immune evasion of neuroblastoma, novel targets that warrant evaluation, and decreased expression of tumor suppressor genes are demonstrated. These studies describe a unique and generalizable approach to expand the utility of transgenic models of spontaneous tumor, providing new tools for preclinical investigation.
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