Journal
CANCER INVESTIGATION
Volume 29, Issue 3, Pages 208-213Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2010.550592
Keywords
Cancer; Colon; Apoptosis; Curcumin
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Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.
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