Journal
NATURAL PRODUCT REPORTS
Volume 24, Issue 5, Pages 972-987Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b703107f
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Funding
- BBSRC [BB/D003997/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D003997/1] Funding Source: Medline
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The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes.
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