Journal
CANCER INVESTIGATION
Volume 29, Issue 6, Pages 396-404Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2011.587071
Keywords
Adenomatous polyposis coli; Apoptosis; Cleaved caspase; Phosphoglycoprotein 170; Flavone
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Funding
- Deutsche Forschungsgemeinschaft [WE 2684/7-1, WE 2684/7-2]
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APC(min/+) mice, carrying a nonsense mutation in the adenomatous polyposis coli (APC) gene, appear as a perfect model to study development or therapy of intestinal neoplasia. We tested whether the flavonoid flavone is able to affect adenoma development in APC(min/+) mice. Tumor sizes were significantly increased by flavone selectively in small intestine. This was associated with reduced cell numbers displaying cleaved caspase-3 and enhanced expression of phosphoglycoprotein (P-gp). However, according to great variability in P-gp expression in all parts of mice intestines, an association between expression of P-gp and inhibition of apoptosis was demonstrated in human Caco-2 colorectal cancer cells.
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