Journal
CANCER INVESTIGATION
Volume 29, Issue 4, Pages 318-324Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2011.554477
Keywords
MiRNA expression profile; PSA; Positive predictive value; Prostate cancer
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Funding
- National Cancer Institute [P20 CA118770, U54 CA091431, NCRR/NIH 2G12 RR003048]
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Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cultured prostate cell lines and 20 human prostate specimens. We found that the miRNA expression profiles were significantly different between nontumorigenic and tumorigenic cell lines and specimens. Positive predictive value analysis of prostate cancer was increased from 40%% to 87.5%% by integrating patient PSA blood levels with miR-21 and miR-141 profiles.
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