Journal
CANCER INVESTIGATION
Volume 28, Issue 6, Pages 661-669Publisher
INFORMA HEALTHCARE
DOI: 10.3109/07357901003735634
Keywords
Matrix Metalloproteinase 2; NSCLC; Meta-analysis; Prognosis
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Funding
- Nanjing Sanitary Bureau of Jiangsu Province
- Jiangsu province Natural Science Foundation of China [2008]
- Foundation of Jiangsu Key Researchers in Medical Science of China [RC2007113]
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To evaluate the prognostic value of Matrix Metalloproteinase2 (MMP-2) expression in patients with non-small cell lung cancer (NSCLC), the electronic database PubMed, EMBASE were searched for relevant articles. The meta-analysis was finally based on 11 studies that included 1,439 patients, and combined HR was 1.66 (95% confidence intervals (Cl: 1.37-2.01). Its effect also appeared significant when the analysis was restricted to tumor cell expression and patients with adenocarcinoma (HR 2.08 (95% Cl: 1.24-3.48)). This study supported the fact that MMP-2 could be included in further prospective trials studying prognostic factors in NSCLC.
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