Journal
DEPRESSION AND ANXIETY
Volume 24, Issue 7, Pages 495-517Publisher
WILEY
DOI: 10.1002/da.20262
Keywords
GABA; anxiety; depression; benzodiazepine receptors; common pathogenesis
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Funding
- Intramural NIH HHS Funding Source: Medline
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This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.
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