Journal
CANCER INVESTIGATION
Volume 28, Issue 10, Pages 1013-1018Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900802620844
Keywords
E-cadherin; Small activating RNA; Prostate cancer; Invasion
Categories
Funding
- National Natural Science Foundation of China [30770832]
- Zhejiang Provincial Natural Science Foundation of China [Y207415]
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Small activating RNAs are a recently discovered group of small, noncoding, and double-stranded RNA molecules that can induce sequence-specific transcriptional gene activation by targeting gene promoter regions. In the present study, we demonstrate that induction of E-cadherin expression by small activating RNA leads to suppression of migration and invasion of PC3 prostate cancer cells. The inhibitory effect was associated with relocalization of beta-catenin from the nucleus to the plasma membrane and decreased beta-catenin-mediated transactivation. These data suggest that activation of E-cadherin by small activating RNA may have a therapeutic benefit for prostate and other types of cancer.
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