Journal
CANCER INVESTIGATION
Volume 28, Issue 7, Pages 689-697Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357901003735642
Keywords
Urokinase plasminogen activator; Breast cancer; Metastasis
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Funding
- National Basic Research Program of China [2004CB518805]
- National High Technology Research and Development Program of China [2006AA02A255]
- National Natural Science Foundation of China [30530810]
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Urokinase plasminogen activator (uPA) correlates closely with breast cancer metastasis via triggering the degradation of divergent matrix proteins. Here, uPA was selectively knocked down in breast carcinoma MDA-MB-231 cells by siRNAs. The in vitro migration of MDA-MB-231 cells was effectively suppressed accompanied by a decrease in extracellular MMP-9 activities. The colony formation ability of MDA-MB-231 cells was inhibited following uPA knockdown, while the proliferation was not affected. The uPA knockdown in MDA-MB-231 cells caused significantly suppressed tumor metastasis in nude mice. Thus, siRNAs targeted to uPA have implications in the development of novel approaches to preventing breast cancer metastasis.
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