Journal
CANCER INVESTIGATION
Volume 27, Issue 7, Pages 723-733Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802672712
Keywords
Apoptosis; Bcl-2 protein; Breast cancer; MCF-7 cells; Ursolic acid
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Funding
- Foundation and the General Secretariat of Research and Technology, Ministry of Development, Greece
- ELPEN Company
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In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells. The UA-induced apoptosis (53 M), the PARP cleavage, and the decrease in Bcl-2 protein (53 M) support the notion that UA induces apoptosis through the intrinsic mitochondrial pathway. UA binds GR (relative binding affinity: 2.57) and translocates GR into nucleus, suggesting its potential as a GR modulator. UA had no effect on GRE- or TRE-driven gene expression. In summary, UA is a GR modulator and may be considered as a potential anticancer agent in breast cancer.
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