Journal
CANCER INVESTIGATION
Volume 27, Issue 3, Pages 329-333Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802392675
Keywords
CD147 (EMMPRIN, Basigin); Melanoma model; Angiogenesis; Metastasis
Categories
Funding
- Wilhelm-Sander-Stiftung, Munich, Germany [2000.056.2]
Ask authors/readers for more resources
CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis formation and angiogenesis in this model, CD147 was stably knocked down in B16 cells. This silencing of CD147 expression resulted in a reduced capability of the tumor cells to metastasize to the draining lymph nodes. Notably, the CD147 knock down caused a decreased VEGF expression in vivo accompanied by reduced blood vessel formation. Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available