Journal
CANCER INVESTIGATION
Volume 27, Issue 1, Pages 52-59Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802146204
Keywords
Ovarian cancer; Foxo3a; p27kip1
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Funding
- National Natural Scientific Foundation of China Grant [30300099, 30770488]
- Natural Scientific Foundation of Jiangsu Province Grant [BK2003035, BK2006547]
- College and University Natural Scientific Research Programme of Jiangsu Province [03KJB180109, 04KJB320114]
- Technology Guidance Plan for Social Development of Jiangsu Province Grant [BS2004526]
- Health Project of Jiangsu Province [H200632]
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To investigate whether Foxo3a expression is correlated with p27kip1 protein levels as well as how it might be clinically relevant, we evaluated the expression of Foxo3a in several ovarian tumors. Immunohistochemical analysis was performed in 63 cases of ovarian tumors. Ten cases were evaluated by Western blot analysis. There was a correlation observed between Foxo3a over-expression and clinic pathological parameters (p = 0.032). Kaplan-Meier survival analysis showed that Foxo3a low expression was significantly associated with poor prognosis of patients. It may be a useful prognostic marker and target in ovarian cancer.
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