Journal
CANCER INVESTIGATION
Volume 28, Issue 1, Pages 38-43Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900802672761
Keywords
Colorectal carcinoma; MMP-9; Immunohistochemistry; Clinico-pathological data; Patients survival
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Extracellular matrix degradation is required for invasion and metastasis formation in colorectal carcinoma (CRC), therefore, we have examined matrix metalloproteinases MMP-9 expression in tumors from patients with CRC. The study comprises of 360 patients who underwent bowel resection for stage II, III, IV tumors. Paraffin-embedded CRC tissue samples were used for immunohistochemical staining. Negative MMP-9 expression levels correlated with longer survival time as evaluated by disease-free survival and disease-specific survival (p = .023, p = .006). In multivariate survival (Cox) analysis, MMP9 was a significant independent predictor of DFS (p = .014), but not of DSS, which was independently predicted by disease recurrence, stage and localization. The detection of MMP-9 expression may be valuable in finding patients who are at high risk of developing disease recurrence.
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