Journal
CANCER INVESTIGATION
Volume 28, Issue 5, Pages 544-553Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900903405942
Keywords
Chemotherapy; Cancer treatment; Cognitive impairment; Neural cell proliferation; Neurogenesis; IGF-1
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Funding
- DOD [BC021198]
- NCI [R25CA01618]
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Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-bromo-2-deoxyuridine labeling following chemotherapy given to C57BL/6 mice revealed a similar reduction in neural cell proliferation in the dentate gyrus for all four agents. Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation.
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