Journal
CANCER INVESTIGATION
Volume 27, Issue 7, Pages 734-740Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802620786
Keywords
Smad1; BMPR-IB; Glioma development
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Funding
- Chinese National Science Foundation [30873029]
- Chinese National Key Basic Research Project [2009CB521804]
- National Basic Research Program of China [2004CB518604]
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Here we report the negative correlation of phosphorylation of Smad1 and BMPR-IB expression with the development of human glioma. Western blot analysis showed that expression of both phospho-Smad1/5/8 and BMPR-IB were decreased in malignant glioma tissues compared with normal brain tissues. Kaplan-Meier survival curves revealed that lower expression ratio of phospho-Smad1/5/8 to Smad1 expression significantly correlates with poor patient survival. Transient transfection of BMPR-IB activates Smad1 signaling and induces differentiation and apoptosis of U251 and U87 glioblastoma cells. The effects could be blocked by cotransfection of Smad6. These results might provide new molecular marker and target for glioma diagnosis and therapy.
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