Journal
CANCER INVESTIGATION
Volume 28, Issue 2, Pages 181-185Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357900903095748
Keywords
Fish; TERC gene; Telomerase; Hepatitis C; Non Hodgkin lymphoma
Categories
Ask authors/readers for more resources
Focal amplification of specific regions of the genome creates high copy number and expression of oncogenes in tumors. By applying fluorescence in situ hybridization (FISH) to leukocytes of hepatitis C (HCV) patients and non-Hodgkin lymphoma (NHL) patients, we estimated gene dosage of the TERC gene at 3q26.3. Higher TERC copy numbers were found in NHL at diagnosis compared to HCV patient groups. Higher TERC copy numbers were also observed in NHL patient at diagnosis and relapse compared to patients in remission. We believe that the TERC gene amplification is involved in the process of genetic instability leading to tumor genesis such as in NHL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available