Journal
PEDIATRIC HEMATOLOGY AND ONCOLOGY
Volume 24, Issue 1, Pages 29-44Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010600970468
Keywords
fertility; ovarian tissue cryopreservation; ovarian tissue grafting; pediatric cancer treatment; precocious ovarian failure
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Fertility preservation in childhood cancer has become an important area of investigation due to increasing survival rates after cancer therapy. For these patients with an increased risk of infertility and premature ovarian failure, cryopreservation of ovarian tissue is a promising tool to preserve at least part of the reproductive potential. In recent years significant improvements have been achieved in this area, and 2 live births after autografting of frozen-thawed ovarian tissue have been reported. However, further research is needed to assess the clinical effectiveness of ovarian cryopreservation, to optimize the technique, and to limit the risk of reintroducing cancer cells in the patient with the graft.
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