Journal
CANCER INVESTIGATION
Volume 26, Issue 10, Pages 1008-1014Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802087267
Keywords
Resistin; Protein expression; Colorectal cancer; Polymorphism
Categories
Funding
- Futurum-the academy of healthcare
- County Council of Jonkoping, Sweden
- University College of Health Sciences, Jonkoping, Sweden
Ask authors/readers for more resources
A single nucleotide polymorphism (SNP) -420C> G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420C> G resistin polymorphism is not a potential genetic susceptibility factor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available