Journal
AUTOIMMUNITY
Volume 40, Issue 4, Pages 267-273Publisher
INFORMA HEALTHCARE
DOI: 10.1080/08916930701357208
Keywords
phagocytosis; apoptosis; macrophage; inflammation; autoimmunity
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Funding
- MRC [G0601481] Funding Source: UKRI
- Medical Research Council [G0601481] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with noninflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.
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