Journal
CANCER INVESTIGATION
Volume 26, Issue 9, Pages 923-928Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900801993432
Keywords
DNA copy number; CGH; chromosomal aberration; microarrays
Categories
Funding
- NIGMS NIH HHS [R01 GM082798] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM082798] Funding Source: NIH RePORTER
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Array comparative genomic hybridization (aCGH) is a technique for measuring chromosomal aberrations in genomic DNA. With the availability of high-resolution microarrays, detailed characterization of the cancer genome has become possible. In this review, we discuss several issues in the generation and interpretation of aCGH data, including array platforms, experimental design, and data analysis. Due to the complexity of the data, application of appropriate statistical methods is crucial for avoiding false positive findings. We also describe integration of copy number data with other types of data to identify functional significance of observed aberrations.
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