Journal
IMMUNOLOGIC RESEARCH
Volume 38, Issue 1-3, Pages 347-352Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-007-0006-2
Keywords
primary immunodeficiency; NF-kappa B; toll-like receptors; interleukin-1 receptors; tumor necrosis factor receptors; inflammation; streptococcus pneumoniae
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Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.
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