Journal
AUTOIMMUNITY
Volume 40, Issue 4, Pages 274-280Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930701357463
Keywords
innate immunity; apoptosis; autoimmunity; inflammation; phagocytosis; signal transduction
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Funding
- Canadian Institutes of Health Research [67101] Funding Source: Medline
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Growing evidence exists for a new role for apoptotic cell recognition and clearance in immune homeostasis. Apoptotic cells at all stages, irrespective of membrane integrity, elicit a signature set of signaling events in responding phagocytes, both professional and non- professional. These signaling events are initiated by receptor-mediated recognition of apoptotic determinants, independently of species, cell type, or apoptotic stimulus. We propose that the ability of phagocytes to respond to apoptotic targets with a characteristic set of signaling events comprises a second distinct dimension of innate immunity, as opposed to the traditional innate discrimination of self vs. non- self. We further propose that a loss or abnormality of the signaling events elicited by apoptotic cells, as distinct from the actual clearance of those cells, may predispose to autoimmunity.
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