Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 61, Issue 2, Pages 289-293Publisher
SPRINGER
DOI: 10.1007/s00262-011-1181-5
Keywords
Tumor microenvironment; T cell; Tolerance; Suppression; CITIM 2011
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Funding
- NCI, NIH
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Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
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