Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 31, Issue 4, Pages 585-596Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2006.12.003
Keywords
appraisal; self-relevance; cortical-subcortical systems; introspection
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065723] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021155] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG021155] Funding Source: Medline
- NIMH NIH HHS [R01 MH065723-06, R01 MH065723-05, R01 MH065723-04, R01 MH065723, R01 MH65723] Funding Source: Medline
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We argue that many similar findings observed in cognitive, affective, and social neuroimaging research may compose larger processes central to generating self-relevance. In support of this, recent findings from these research domains were reviewed to identify common systemic activation patterns. Superimposition of these patterns revealed evidence for large-scale supramodal processes, which are argued to mediate appraisal of self-relevant content irrespective of specific stimulus types (e.g. words, pictures) and task domains (c.g. induction of reward, fear, pain, etc.). Furthermore, we distinguish between two top-down sub-systems involved in appraisal of self- relevance, one that orients pre-attentive biasing information (e.g. anticipatory or mnemonic) to salient or explicitly self-relevant phenomena, and another that engages introspective processes (e.g. self-reflection, evaluation, recollection) either in conjunction with or independent of the former system. Based on aggregate patterns of activation derived from the reviewed studies, processes in a ventral medial prefromal cortex (MPFC)-subcortical network appear to track with the former pathway, and processes in a dorsal MPFC-cortical-subcortical network with the latter. As a whole, the purpose of this framework is to re-conceive the functionality of these systems in terms of supramodal processes that more directly reflect the influences of relevance to the self. (c) 2007 Elsevier Ltd. All rights reserved.
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