Journal
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
Volume 33, Issue 6, Pages 769-776Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00952990701651556
Keywords
aripiprazole; cocaine; humans; pharmacotherapy; physiological; effects
Categories
Funding
- NCRR NIH HHS [M01 RR02602] Funding Source: Medline
- NIDA NIH HHS [R01 DA 020429] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR002602] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA020429] Funding Source: NIH RePORTER
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Although cocaine dependence remains a significant public health concern, efforts to identify a pharmacotherapy have been unsuccessful. The purpose of this study was to assess the safety, tolerability, and subject-rated effects of intranasal cocaine during maintenance on aripiprazole, a novel antipsychotic with partial agonist activity at monoamine receptors implicated in the effects of cocaine. To this end, eight cocaine dependent subjects were maintained on 10mg oral aripiprazole and placebo in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine ( 4, 20, 40, and 60 mg). Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose.
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