Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 60, Issue 8, Pages 1061-1074Publisher
SPRINGER
DOI: 10.1007/s00262-011-1053-z
Keywords
Innate immunity; Adaptive T cells; Natural killer cells; Effector function; Immune regulation; Cancer immunotherapy
Categories
Funding
- National Cancer Institute [U54 CA091408]
- National Institutes of Health
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The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.
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