Journal
NATURAL PRODUCT REPORTS
Volume 24, Issue 5, Pages 1041-1072Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b603600g
Keywords
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Funding
- NIDDK NIH HHS [DK16073, R01 DK016073] Funding Source: Medline
- NIGMS NIH HHS [R01 GM100305, R01 GM069717, R01 GM076330-01A2, GM069717, R01 GM076330] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK016073] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM100305, R01GM076330, R01GM069717] Funding Source: NIH RePORTER
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This review chronicles the synergistic growth of the fields of fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases and modular polyketide synthases, similar catalytic elements are covalently linked in the same order in megasynthases. Whereas in fatty acid synthases the basic elements of the design remain immutable, guaranteeing the faithful production of saturated fatty acids, in the modular polyketide synthases, the potential of the basic design has been exploited to the full for the elaboration of a wide range of secondary metabolites of extraordinary structural diversity.
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