Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 128, Issue 1, Pages 106-111Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.11.017
Keywords
replicative life span; chronological life span; genomics; RNAi; calorie restriction
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Funding
- NIA NIH HHS [P30 AG013280, R01 AG024287] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG024287, P30AG013280] Funding Source: NIH RePORTER
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Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are public aging mechanisms. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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