Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 60, Issue 3, Pages 425-431Publisher
SPRINGER
DOI: 10.1007/s00262-010-0967-1
Keywords
Tumor metabolism; Immune escape; Cytotoxic T cells; Lactic acid
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Funding
- IZKF Erlangen [D12]
- Reform C, Regensburg
- [DFG1418/7-1]
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Tumor cells have developed multiple mechanisms to escape T-cell-mediated immune recognition. Recent work has revealed that the altered tumor metabolism depletes essential nutrients or leads to the accumulation of immunosuppressive metabolites in the tumor microenvironment. In this review, we discuss the suppressive activity of some metabolic key players, which are upregulated in human tumor cells, including indolamine-2,3-dioxygenase (IDO), arginase, inducible nitric oxide synthetase (iNOS), and lactate dehydrogenase (LDH)-A, on the adaptive immune system. A better understanding of the impact of metabolic alterations of tumor cells on effector T-cell functions could lead to new therapeutic strategies to improve the efficacy of cancer immunotherapy.
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