Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 59, Issue 5, Pages 675-686Publisher
SPRINGER
DOI: 10.1007/s00262-009-0783-7
Keywords
NF-kappa B; Hh pathway; Monocytes; Pancreatic cancer
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Funding
- Ministry of Education, Culture, Sports and Technology of Japan [21390363]
- Grants-in-Aid for Scientific Research [21390363] Funding Source: KAKEN
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Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammation-stimulated monocytes produce Shh through activation of the NF-kappa B signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.
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