Journal
FRONTIERS IN BIOSCIENCE
Volume 12, Issue -, Pages 5166-5174Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2556
Keywords
ovarian cancer; proteomics; transformation; RAS; tumor susceptibility gene 101; procaspase 4; p21; HIF-1 alpha; CITED2; review
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM066170] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM066170] Funding Source: Medline
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Using a genetically defined human ovarian cancer model, we have analyzed the protein expression profile of human ovarian cancer cells established by oncogenic RAS transformation. Cells were immortalized by retroviral transfection of SV40 t/T antigens and the catalytic subunit of telomerase (hTERT). Careful analyses of protein targets associated with oncogenic transformation have enabled us to identify several novel signaling pathways that play important roles in oncogenic transformation of human ovarian epithelial cells.
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