Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 57, Issue 10, Pages 1559-1568Publisher
SPRINGER
DOI: 10.1007/s00262-008-0553-y
Keywords
dendritic cells; specific immune responses; migration; mRNA transfection; in vivo targeting
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We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.
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