Journal
TRENDS IN CELL BIOLOGY
Volume 17, Issue 9, Pages 428-437Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.06.006
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK057683, P50DK064236, R01DK062472] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA018886] Funding Source: NIH RePORTER
- NIDA NIH HHS [DA18886] Funding Source: Medline
- NIDDK NIH HHS [DK57683, DK062472, DK064236] Funding Source: Medline
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Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
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